Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Effects of plaquenil on hair Chloroquine ocular side effects Can plaquenil cause vasculitis Plaquenil for psoriatic arthritis PLAQUENIL is indicated for the suppressive treatment and treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis. Potential side effects of anti-malarial drugs include Skin rashes and pigment change. Atabrine, specifically, can cause yellow pigmentation of skin. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin. Loss of appetite. Abdominal bloating. Upset stomach. Aug 18, 2009 Ginny, I had some very minor diarrhea, nausea, cramping for about a week when I started Plaquenil. Everyone is different, but for me, taking the med about 15 min. after eating, rather than before or with a meal, makes things much easier on my stomach, even for just Advil. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Cramps and plaquenil Stomach cramps from Plaquenil - what to do? Lupus Forums., Treating Lupus with Anti-Malarial Drugs Johns Hopkins. Chloroquine physical propertiesHydroxychloroquine mode of action Oct 24, 2013 After just 4 days on Plaquenil, I had severe stomach cramps, no appetite, GERD pain, diarrhea and a migraine. Not sure that the migraine was related but it happened on day 4. After contacting my Rheumatologist, I was told to stop taking the drug. Stomach cramps from Plaquenil - what to do? Lupus Forums at.. Plaquenil = explosive diarrhea -. Plaquenil Uses, Dosage & Side Effects -. Applies to hydroxychloroquine oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Nocturnal leg cramps are a common cause of pain in the legs that can disrupt sleep. They are present in nearly 50 percent of those over the age of 50. Leg cramps are characterized by sudden muscle tightness, most commonly in the foot, thigh, or calf, that may last from seconds to minutes. I've been taking Plaquenil 400 mg for nearly 6 mos. I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile.