Quinacrine hydrochloride also has the 4-amino quinoline radical but has, in addition, a benzene ring; it is classified as an acridine compound. The 4-amino quinoline radical is present in all antimalarial compounds shown to be effective in the treatment of lupus erythematosus (LE) (Figure). Hydroxychloroquine mechanism of action arthritis Does plaquenil affect your immune system Cutaneous lupus erythematosus CLE is the second most common presenting symptom of autoimmune lupus erythematosus LE. Lesions precede the onset of systemic symptoms in 25 percent of patients, many of whom present to dermatologists for their initial evaluation.1 Prompt diagnosis of CLE requires a thorough understanding of the cutaneous manifestations and clinical spectrum of lupus. One of the key goals of the Lupus Foundation of America Foundation is to ensure people with lupus have access to the care and treatments they need. Recently, access to a few vital treatments has been challenging to obtain, specifically access to quinacrine, hydroxychloroquine, and Benlysta®. In. Plaquenil is an extremely safe medication, with few side effects gastrointestinal complaints the first 2-3 weeks are the most common. It has numerous benefits on lupus and in general tends to lower cholesterol for instance. It is interesting that you were first prescribed mepacrine/quinacrine instead of Plaquenil. Its superiority over quinine was established during World War II, when it became the official drug for the treatment of malaria. Quinacrine was introduced for malaria therapy in 1930. Quinacrine and hydroxychloroquine lupus profundus Discoid Lupus Erythematosus Medication Antimalarial agents., Access to Treatments Lupus Foundation of America Plaquenil toxicity cureSide effects of plaquenil and prednisoneHydroxychloroquine blurred vision due to A variety of antimalarial medications have been shown to be effective for systemic rheumatic diseases since quinine was first used to treat systemic lupus erythematosus SLE more than 100 years ago. Three of these drugs are now primarily used due to their safety profile. Chloroquine and hydroxychloroquine HCQ are 4-aminoquinoline derivatives. REFERENCES - UpToDate. Antimilarials - Quinacrine and Plaquenil? Lupus Forums at.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Lupus panniculitis, or lupus profundus, is a variant of lupus erythematosus that primarily affects subcutaneous fat. In nearly all cases there are deep, erythematous plaques and nodules, and some ulcers, which usually involve the proximal extremities, trunk, breasts, buttocks, and face. Treatment of recalcitrant cutaneous lupus erythematosus CLE is challenging. It was revised and improved in 2010 to take the different subtypes of CLE – especially lupus erythemathosus profundus and LET – into account 4. Ceribelli A, Zane C, Cattaneo R, et al. Treatment of lupus skin involvement with quinacrine and. Lupus erythematosus panniculitis LEP is characterized by chronic and recurrent subcutaneous inflammatory lesions and is considered a form of chronic cutaneous lupus erythematosus CLE. Clinically, LEP appears as erythematous, deeply indurated, tender plaques and nodules.