Plaquenil use with retinopathy

Discussion in 'Canadian Drugs' started by wthf, 28-Feb-2020.

  1. f-a-n-t-o-m XenForo Moderator

    Plaquenil use with retinopathy


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

    Plaquenil 200mg таблетки Plaquenil retinopathy autofluorescence Plaquenil and pepcid

    Hydroxychloroquine is the most commonly used AM, specifically because it has a lower risk for retinal toxicity than chloroquine. This may be because CQ crosses the blood-retinal barrier and HCQ does not. There is no retinal damage associated with the use of quinacrine. HCQ is widely used for the treatment of rheumatic diseases, particularly lupus and RA. It is generally well tolerated, but retinopathy is a concern. Retinopathy is rare, but is sight threatening, generally irreversible and may progress even after cessation of therapy. Damage may be subclinical. Hydroxychloroquine Plaquenil; HCQ has been an important and effective drug for the treatment of lupus erythematosus and related autoimmune and inflammatory diseases for half a century, although its potential to cause retinal damage continues to raise concern among rheumatologists and ophthalmologists.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Plaquenil use with retinopathy

    Recommendations on Screening for Chloroquine and., Hydroxychloroquine-related retinal toxicity Rheumatology.

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  5. These data suggest that hydroxychloroquine retinopathy is more common than previously recognized, especially at high daily intake and with long durations of use or in the presence of kidney disease or concurrent tamoxifen therapy. Daily use of 5.0 mg/kg of real body weight or less is associated with a low risk for up to 10 years of use.

    • Toxic Retinopathy With Hydroxychloroquine Therapy - JAMA.
    • Hydroxychloroquine Retinopathy Still Alive and Well - The..
    • Taking Plaquenil for Rheumatoid Arthritis.

    Hydroxychloroquine retinopathy is characterized by a bulls eye maculopathy and is associated with corneal verticillata.2,5,6 The reported incidence of toxic retinopathy associated with chloroquine varies from 1% to 16%; there is a lesser incidence associated with hydroxychloroquine.6,8 The exact mechanism of action of hydroxychloroquine remains. Studies have shown that patients who have manifested with retinopathy have traces of Plaquenil metabolites in their erythrocytes, plasma, and urine even after 5 years of discontinuing the medication 1, 2, 3. Postmarketing cases of lifethreatening and fatal cardiomyopathy have been reported with use of PLAQUENIL as well as with use of chloroquine. Patients may present with atrioventricular block, pulmonary hypertension, sick sinus syndrome or with cardiac complications.

     
  6. Vasiliy2008 XenForo Moderator

    Selected from data included with permission and copyrighted by First Databank, Inc. Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs. Hydroxychloroquine toxicity - EyeWiki Protecting your eyesight when taking Plaquenil Lupus.
     
  7. Condenser User

    In some cases, they may not be available in every strength or form as the brand-name drug. Hydroxychloroquine - Wikipedia Hydroxychloroquine Plaquenil Plaquenil 200mg plėvele dengtos tabletės N60 - Vaistai.lt
     
  8. curixmann New Member

    Efficacy and Safety of Hydroxychloroquine for Treatment of Pneumonia. Efficacy and Safety of Hydroxychloroquine for Treatment of Pneumonia Caused by 2019-nCoV HC-nCoV The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

    Hydroxychloroquine Professional Patient Advice -
     
  9. Darth Vaider Well-Known Member

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. A baseline ocular examination is recommended within the first year of starting PLAQUENIL. The baseline exam should include best corrected distance visual acuity BCVA, an automated threshold visual field VF of the central 10 degrees with retesting if an abnormality is noted, and spectral domain ocular coherence tomography SD-OCT.

    Has anyone experienced plaquenil toxicity with damage to eyes?