Chloroquine eye toxicity

Discussion in 'Certified Online Canada Pharmacy' started by telefunken, 25-Feb-2020.

  1. SKYNS Well-Known Member

    Chloroquine eye toxicity


    Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention.

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    To reduce the incidence of chloroquine and hydroxychloroquine toxicity, health care providers HCP's that prescribe these medications and those that screen for ocular toxicity have developed clear dosing and screening protocols that have reduced the risk of end-stage disease; bull's eye maculopathy and central vision loss Level I. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease.

    Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine.

    Chloroquine eye toxicity

    Retinal toxicity associated with chronic exposure to., Chloroquine retinopathy - Wikipedia

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  7. Chloroquine phosphate tablets should not be used in these conditions unless the benefit to the patient outweighs the potential risks. Usage in Pregnancy Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus.

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    In view of the fact that all electron micro scopic studies on chloroquine toxicity in the eye have to date been limited to experimental animals, and because our experience has shown that tissues routinely fixed in Forma lin may occasionally be helpful in such stud ies,2 we decided to re-examine the material available from Wetterhold and Winter. Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. In 1959, Hobbs established a definite link between long-term use of chloroquine and subsequent development of retinal pathology. In 1962, J Lawton Smith coined the term bull's eye maculopathy, regarded as the classic finding of macular toxicity. Many reports on chloroquine retinopathy exist.

     
  8. mardokSP Moderator

    Download PDF Many systemic medications may cause retinal toxicity. Rx Side Effects New Plaquenil Guidelines and More. Will you have Vitreous floaters with Plaquenil - eHealthMe Hydroxychloroquine-Induced Retinal Toxicity - American.
     
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