Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. How to take plaquenil twice daily Hydroxychloroquine hearburn Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. PLAQUENIL has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with or without antidiabetic with caution in patients with gastrointestinal, neurological, or blood disorders, and in those with a sensitivity to quinine. Yes, plaquenil can cause low blood sugars. Eat frequent meals with carbs and protein but good carbs with fiber like oatmeal or whole wheat toast with peanut butter. I like the lowered blood sugar effect b/c I have type 2 diabetes but before I got type 2, I had some low sugars with plaquenil for sure. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Cases of long-term use of plaquenil causing low-blood sugar Plaquenil Hydroxychloroquine Sulfate - Sanofi, Plaquenil – Plaquenil capsule Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil and low blood sugar -. Plaquenil & Nausea - Autoimmune diseases - Inspire. Aug 14, 2017 Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Plaquenil may be used for short or long-term rheumatoid arthritis treatment. In treating rheumatoid arthritis, Plaquenil may slow down the process of joint damage and relieve the symptoms of the. Hydroxychloroquine oral tablet is used for short-term treatment of malaria, but it may be used for long-term treatment of lupus or rheumatoid arthritis.