Dark-skinned persons may experience generalized pruritus that is not indicative of drug allergy. Retinal toxicity that may occur with long-term high doses of chloroquine used in the treatment of other diseases is extremely unlikely with chloroquine given as a weekly malaria chemosuppressive agent. Plaquenil and depression and anxiety Plaquenil guidelines aao Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a carrier and which is the protonation state of its chloroquine substrate is the subject of a. Original Article. The Molecular Basis of the Action of Chloroquine in Porphyria Cutanea Tarda. A single therapeutic dose of chloroquine, a 4 aminoquinoline, administered to patients with porphyria cutanea tarda PCT results in a massive porphvrinuria with subsequent remission at the disease. Because insufficient drug is excreted in breast milk to protect the infant, nursing infants should be given chloroquine. Chloroquine use is suitable for people of all ages and for pregnant women. Chloroquine method of action Chloroquine Modes of action of an undervalued drug., On the Mechanism of Chloroquine Resistance in Plasmodium. Mycophenolate and plaquenilDays plaquenil to workChloroquine show up on a drug testPlaquenil for gvhdPlaquenil alternatives lupus Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells. Chloroquine is effective against the malarial parasites Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. Aralen chloroquine Medication Junction. The Molecular Basis of the Action of Chloroquine in Porphyria.. Malaria - Diagnosis and treatment - Mayo Clinic. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Chloroquine works best when you take it on a regular schedule. For example, if you are taking it once a week to prevent malaria, it is best to take it on the same day of each week. Make sure that you do not miss any doses. If you have any questions about this, check with your doctor.