Plaquenil retinopathy autofluorescence

Discussion in 'Northwest Pharmaceuticals Canada' started by snark, 06-Mar-2020.

  1. amolodoy Well-Known Member

    Plaquenil retinopathy autofluorescence


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. Although multifocal electroretinogram mfERG and fundus autofluorescence FAF are not currently primary tests used in the evaluation of Plaquenil retinal toxicity, they may be beneficial when the diagnosis or findings are enigmatic or an adjunct test is warranted. Figure 1 is an image of an ocular fundus using autofluorescence to designate an area of retinal damage. To detect chloroquine toxicity, the American Academy of Ophthalmology recommends performing fundus examinations, 10-2 automated visual fields, and at least one objective test multifocal electroretinography mfERG, fundus autofluorescence.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Plaquenil retinopathy autofluorescence

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  6. Ultra-widefield fundus autofluorescence images placed in order of severity in the eyes with hydroxychloroquine retinopathy with a parafoveal dominance pattern. Retinopathy varies from ring-shaped parafoveal hyperautofluorescence to round macular hypoautofluorescence and finally to bull's eye maculopathy with peripheral involvement rightmost.

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    Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Retinal Diseases; Home; Hydroxychloroquine Retinopathy-Fundus Autofluorescence. Fundus autofluorescence image of a 46-year-old woman with systemic lupus erythematosus who had taken chloroquine for 17 years at a dosage of 500 mg/d. Based on her actual body weight, which was ideal, she had been overdosed at 8.8 mg/kg/d and had received a. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1.

     
  7. mView Well-Known Member

    500 mg chloroquine phosphate (300 mg base) orally on the same day each week Comments: -If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate (600 mg base) may be taken orally in 2 divided doses, 6 hours apart. Breakthrough Chloroquine phosphate shows efficacy in. Chloroquine Phosphate - WebMD Discoid Lupus Erythematosus Medication Antimalarial agents.
     
  8. Ark2006 Well-Known Member

    Lupus Treatment, living with lupus, and prevention Hydroxychloroquine Plaquenil This is an antimalarial drug. It can help to keep mild lupus-related symptoms — such as fatigues, skin, and joint problems — under control.

    Hydroxychloroquine Use and Risk of CKD in Patients with Rheumatoid.
     
  9. ElectroD User

    PLAQUENIL TBL 200MG N60 9.09€. Lietošanas. Ieteicamā Plaquenil deva pieaugušajiem ir 400 mg 2 tabletes dienā šo devu var sadalīt un dienas laikā lietot vairākās devās. Ārsts devu var Jums samazināt līdz 200 mg 1 tabletei dienā. Norijiet tabletes kopā ar ūdeni, ēdienu vai glāzi piena.

    PLAQUENIL 200mg - Pret Pret