I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Hydroxychloroquine sulfate side effecys Does plaquenil help sjogren& 39 Methotrexate plaquenil alcohol Methotrexate strong. You were weaned off Plaquenil hydroxychloroquine and started on methotrexate. Your therapy has been escalated. The Methotrexate is working and that is good. Your doctor will be involved with you for your connective tissue disorder for a long time. Hope this helps. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. Since the side effect of vision loss is possible but rare, it is important for you to tell your doctor about any vision changes that you experience. Doctors generally recommend regular eye exams while on Plaquenil, so that early changes can be caught. Once abnormalities are discovered, toxicity has already occurred. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Do you have to be weaned off of plaquenil Stopping Methotrexate • Johns Hopkins Arthritis Center, What is the correct way to discontinue use of plaquenil? Chloroquine mechanism malaria One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The Risk of Retinal Toxicity with Plaquenil. Taking Plaquenil for Rheumatoid Arthritis. Let me tell you what weaning down from Plaquenil is like.. If you don't have to, don't stop your plaquenil. I stopped taking the plaquenil the beginning of December. It doesn't agree with my stomach I take it with meals too. And since I hadn't had a miraculous recovery the 6 months I'd been on it, I didn't think there was any harm in stopping it. Does anyone know if you have to be weaned off Plaquenil? I've been on it for 15 years, for Lupus? Asked by Lupie523 Updated 27 September 2018 Topics plaquenil, lupus erythematosus, insomnia, sjogren's syndrome, systemic lupus erythematosus, vision If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you, do not stop taking hydroxychloroquine without talking to your doctor. Symptoms of rheumatoid arthritis will return if you stop taking hydroxychloroquine.