Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine antimalarial side effects Mylan pharmaceuticals hydroxychloroquine Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. So far it’s been okay, no major side effects. Except today I started having some heartburn after taking it. It says on the bottle I can’t take an antacid for at least four hours after taking the Plaquenil. Has anyone else experienced heartburn while taking Plaquenil and if so what did you do to avoid or ease the heartburn? If you have psoriasis, chloroquine Aralen and hydroxychloroquine Plaquenil can cause problems. Other Medicines That Might Trigger a Flare. A few other drugs to discuss with your doctor include Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil and omeprazole Is Your Medicine Triggering Scary Atrial Fibrillation AFib., Plaquenil and heartburn rheumatoid Hydroxychloroquine with methotrexate combination steroidVitamin c and plaquenil Omeprazole is in a class of drugs known as proton pump inhibitors that decrease stomach acid. Known as Prilosec in its over-the-counter form, omeprazole is prescribed for acid reflux disease, heartburn and stomach ulcers. Hydroxychloroquine and Omeprazole interaction Treato. Drugs & Medications That Can Trigger Psoriasis Flare-Ups. Methotrexate and Proton Pump Inhibitors. Summary Drug interactions are reported among people who take Omeprazole and Hydroxychloroquine sulfate together. This study is created by eHealthMe based on reports of 1,041 people who take Omeprazole and Hydroxychloroquine sulfate from Food and Drug Administration FDA, and is updated regularly. What is Omeprazole? Omeprazole has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. Check the latest outcomes from 242,382 Omeprazole users, or browse all drugs. What is Plaquenil? Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. May 26, 2014 I pretty much solved the problem by taking the Plaquenil with full meals and by adding a Probiotic. I think the Probiotic helped the most. After I started the Probiotic, the loose stools pretty much stopped, although I do seem to have more stools than I used to have before starting Plaquenil.