In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Hydroxychloroquine immunosuppressive Lupus remission and plaquenil Mechanism of chloroquine resistance This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The side effect that is of greatest concern is retinal toxicity. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. Plaquenil is used in the treatment of sarcoidosis but its main use is in the treatment of malaria. One of the side effects of taking the drug is that it affects eye sight, and eye tests, especially field of vision tests need to be done every six months. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Plaquenil side effects from the n eyes Plaquenil and Trazodone hydrochloride drug interactions., Rx Side Effects New Plaquenil Guidelines and More. Hydroxychloroquine causing rash where For the Consumer. Continuing ringing or buzzing or other unexplained noise in the ears. feeling of constant movement of self or surroundings. irritability. nausea. nervousness. nightmares. sensation of spinning. shakiness and unsteady walk. uncontrolled eye movements. unsteadiness, trembling, or. Plaquenil Side Effects Common, Severe, Long Term -. Plaquenil Withdrawal – Life As An Anomaly. What Is Plaquenil? - American Academy of Ophthalmology. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Call your doctor immediately or get emergency medical help if you experience any of the following serious side effects Any vision problems, such as reading difficulties, sensitivity to light, seeing light flashes or streaks, blurred distance vision, or other issues Hearing problems. Common hydroxychloroquine side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. This is not a complete list of side effects and others may occur.