Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Is plaquenil used to treat sjogren& 39 Plaquenil pill Three cohorts of 3 patients will receive chloroquine in escalating doses 3 dose levels 200 mg up to 600 mg daily during standard treatment radiotherapy and temozolomide for newly diagnosed GBM. Extra patients can be added to a cohort in case of dose limiting toxicity, resulting in a maximum of 6 patients per dose level. There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers. While there is considerable evidence for the efficacy and. Feb 24, 2017 Currently, mebendazole is part of a phase I clinical trial for patients with newly diagnosed, high-grade glioma and glioblastoma. Similarly, the anti-malarial compound chloroquine showed surprising properties in combating cancer and tumor growth in a series of experiments led by a group at the University of Kentucky. In a metastatic cancer mouse model, chloroquine led to the production of a specific tumor suppressor protein called Par-4. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine clinical trials glioma Chloroquine in glioblastoma—New horizons for an old drug., Frontiers Re-purposing Chloroquine for Glioblastoma. Visual field testing for plaquenil toxicityHydroxychloroquine retinopathy side effectsChloroquine hypnozoites The Addition of Chloroquine to Chemoradiation for Glioblastoma, Study Purpose Glioblastomas GBM are the most common type of primary brain tumors with an annual incidence of approximately 500 patients in the Netherlands. The Addition of Chloroquine to Chemoradiation for Glioblastoma.. Double Duty Repurposing Drugs for Novel Cancer Treatment.. Study protocol of a phase IB/II clinical trial of.. Find clinical trials to treat adult glioblastoma. This phase II trial studies the side effects and how well low-dose whole-brain radiation therapy and temozolomide work in treating patients with newly diagnosed glioblastoma multiforme. The COC Protocol in Glioma. Glioma tumors grow from glial cells in the brain and are the most common type of brain tumor. Low-grade benign gliomas are slower growing and less dangerous than high-grade, aggressive malignant gliomas. Glioblastoma multiforme GBM, a type of malignant astrocytoma, is the most common high-grade brain tumor in adults. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of.