Premature ejaculation (PE) is a distressing male sexual dysfunction that can be present from the first sexual encounter or can develop later in life. Men with premature ejaculation appear to go through the same process of ejaculation as other men, but it happens more quickly and with a reduced feeling of control. A combination of physiological and psychological factors is believed to impact on ejaculatory latency, and research suggests that serotonin plays a central role. The negative consequences of premature ejaculation are significant they cause: sexual dissatisfaction, personal distress, interpersonal difficulty, low self-esteem, and they may affect partner satisfaction. Priligy (dapoxetine) is the first oral medication approved for "on-demand" premature ejaculation treatment. Priligy is a unique, short-acting, selective serotonin reuptake inhibitor designed to be taken only when needed - one to three hours before sexual intercourse is anticipated - rather than every day. 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