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    Promethazine was developed in the mid-1940s when a team of scientists from the French chemical manufacturing company Rhône-Poulenc combined phenothiazine and a diamine side chain of diphenhydramine to create a new drug. Their creation, promethazine, is a synthetic medication that belongs to a pharmaceutical family known as phenothiazines. As a medication, promethazine has several uses, including treating allergies, motion sickness, and more. It is also a strong sedative that is sometimes prescribed during labor, before and after surgery, and at other times. Promethazine is a first generation antihistamine that is only available by prescription. It effectively treats several conditions, such as: As an antihistamine, promethazine competes with histamine for binding at some of its receptor sites (H1-receptors), thereby blocking histamine from binding to many. This, in turn, prevents or reduces the typical effects of histamine activating those receptors, including hives, constriction of the airways, nausea, increased wakefulness, nasal congestion, sneezing, and a runny nose. Promethazine is an antihistamine medicine that relieves the symptoms of allergies. It's more likely to make you feel sleepy than other antihistamines. It's used for: You can buy promethazine from pharmacies, where it's often sold as Avomine, Phenergan or Sominex. You can also buy promethazine mixed with other medicines, such as paracetamol, dextromethorphan, pholcodine or pseudoephedrine, to treat coughs and colds or pain. Popular brand names include Day & Night Nurse and Night Nurse. It comes as tablets, capsules and a liquid that you swallow. If you or your child have been prescribed promethazine, follow your doctor's instructions about how and when to take it. Only take promethazine when you need it - for example, if you're unable to sleep because you're worrying about something or your cold symptoms are keeping you awake. Promethazine comes in 10mg, 20mg and 25mg tablets and a liquid that you swallow.

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