As such, its IUPAC systematic name is methylbenzene. Toluene is predominantly used as an industrial feedstock and a solvent. As the solvent in some types of paint thinner, contact cement and model airplane glue, toluene is sometimes used as a recreational inhalant In 1841, French chemist Henri Étienne Sainte-Claire Deville isolated a hydrocarbon from balsam of Tolu (an aromatic extract from the tropical Colombian tree Myroxylon balsamum), which Deville recognized as similar to Walter's rétinnaphte and to benzene; hence he called the new hydrocarbon benzoène. Because the methyl group has greater electron-releasing properties than a hydrogen atom in the same position, toluene is more reactive than benzene toward electrophiles. It undergoes sulfonation to give p-toluenesulfonic acid, and chlorination by Cl to give ortho and para isomers of chlorotoluene. Importantly, the methyl side chain in toluene is susceptible to oxidation. 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Although not all of these side effects may occur, if they do occur they may need medical attention. unusual tiredness or weakness unusual weight gain or loss. sore on the skin of the breast that does not heal stomach or pelvic discomfort, aching, or heaviness Rare. The burden of fatigue has now overtaken nausea and pain as the most distressing symptom during chemotherapy. It has been described as tiredness, exhaustion, depression, feeling unwell, loss of motivation and limitation of mental state. Over 75% of patients complain of fatigue and in up to a third this can be severe, considerably impacting their quality of life and ability to care for themselves and others. Fatigue and tiredness can have a negative impact on cancer management by impairing nutritional state, reducing compliance or preventing the required dose being administered. reported that about a third of consultants felt that fatigue was the most important symptom for their patients whilst nearly 70% of the same patients described it as the worst side effect of chemotherapy. Fatigue can also persist post treatments, A recent study in women who had completed adjuvant chemotherapy for breast cancer eloquently demonstrated the extent of this problem in a group of women, many of whom had children to look after or get back to work. Over half reported significant fatigue at 6 months and 20% at a year had not causes of fatigue need to be excluded, many other which, particularly an under active thyroid, can be easily treated. If you are in the process of weaning yourself off of tamoxifen (and there are many reasons why you might want to do so) and need help with the resulting withdrawal side effects, this article shares some tried and true natural remedies to help you out. There are many reasons for these side effects but the major one is that while tamoxifen initially acts as an estrogen-blocker, over time it begins to have estrogen-like activities. When a person has been on tamoxifen for a lengthy period (and that time period varies between people) they can begin to metabolize the drug as they would estrogen, so withdrawing from it can bring on quite a few menopausal symptoms. Dr Scott M Sedlacek, an oncologist with Colorado Breast Specialists in Denver stated back in 1998 that when a woman stops taking the drug, she can experience estrogen withdrawal. 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